Why shouldn’t allopurinol be taken during acute gout?

2022-07-16 0 By

When Lao Wang suffered from gout, he took allopurinol, which made the pain worse.I was informed that I was in the acute phase of gout and could not take allopurinol when I went to the hospital for examination. Why?Allopurinol is a drug that inhibits urea synthesis and is mainly used in patients with recurrent or chronic gout.Allopurinol in the acute phase of gout not only has no anti-inflammatory and analgesic effect, but also can reduce the uric acid crystals in tissues and reduce blood uric acid too fast, which causes the surface dissolution of tophi in joints and the formation of insoluble crystals, aggravating the inflammatory response and causing the acute attack of gout arthritis.The natural course of gout can be divided into four stages: asymptomatic hyperuricemia stage, acute stage, intermittent stage and chronic stage.The principle of acute gout treatment is to quickly control the symptoms and pain of arthritis, preferably within 24 hours of the onset of acute inflammation control drugs, including celecoxib, etocoxib and other non-steroidal anti-inflammatory drugs, and colchicine.To control gout, in addition to following the medication guidance of doctors or pharmacists according to the examination results, we should strictly control daily diet, adhere to exercise and work and rest rules.